Response Of Subcutaneous Administration Of Different Doses Of Aqueous Extract Of Datura Stramonium Linn Seeds On Liver Enzymes
Keywords:
albino rat, aqueous extract, Datura stramonium Linn, hepatotoxicity, liver enzymes activitiesAbstract
To evaluate the effect of aqueous extracts of Datura stramonium seeds on the enzymes activity and to identify the hepatotoxicity of aqueous extracts in white albino rats. Effect of aqueous extract of the seed of Datura stramonium Linn was experimented for liver enzymes activities in forty white albino rats (200- 250g). Plant extracts (aqueous) were tested for their effect on the enzyme activity at four dose levels: 0.02, 0.04, 0.06, 0.08ml/kgbodyweight (BW) and 0 (saline) levels served as control. The extracts were administered via subcutaneous route for ten consecutive days using completely randomized design and the histological studies of the livers were carried out to confirm their hepatotoxicity activity. The result of the study revealed among others that the extract had significant (p<0.05) effect on the liver enzyme activities. This elevation may be an indication of hepatotoxicity of the treated rats resulted from the high dose of aqueous extract. The significant activity exhibited by the aqueous extract on the animals has provided scientific justification for the ethno medicinal uses of the plant in India and South Africa.
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