Pattern of Maternal Serum Alpha-Foetoprotein Immediately Post Partum in Sokoto State, Nigeria

Authors

  • A. F. Abubakar Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences College of Health Sciences, Usmanu Danfodiyo University Sokoto, Nigeria
  • S. C. Das Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences College of Health Sciences, Usmanu Danfodiyo University Sokoto, Nigeria
  • A. S. Mainasara Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences College of Health Sciences, Usmanu Danfodiyo University Sokoto, Nigeria
  • O. Ben Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences College of Health Sciences, Usmanu Danfodiyo University Sokoto, Nigeria
  • A. Bello Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences College of Health Sciences, Usmanu Danfodiyo University Sokoto, Nigeria
  • A. A. Umar Department of Morbid Anatomy and Forensic Medicine, Faculty of Basic Medical Sciences, College of Health Sciences Usmanu Danfodiyo University, Sokoto, Nigeria

Keywords:

Serum alpha-fetoprotein, Reference range, Mother, Sokoto

Abstract

Numerous studies have reported the reference range of maternal serum alphafoetoprotein immediately postpartum, which could help in screening, diagnosis and monitoring of intrauterine anomaly during pregnancy. However such studies are lacking in Sokoto metropolis. The objective of this study is to determine the reference range of maternal serum alpha-fetoprotein (MSAFP) immediately post partum and its association to parity, body mass index (BMI) and 1-minute Apgar score of the babies. A cross-sectional descriptive study was conducted in some selected hospitals in Sokoto metropolis, between March and November 2012.
Using semi-structured questionnaire, data on Parity of mothers and 1-minute
Apgar score are collected. Four millilitres of peripheral blood are collected
immediately post delivery of placenta to determine the MSAFP using Enzyme
linked Immunosorbent assay (ELISA) Method. The data was processed using
analyse it 221t, the Pd” 0.05 is considered statistically significant. The MSAPF
values are analysed using descriptive statistics. The association between the
variables is analysed using Pearson/spearman correlation. The mean and
standard deviation of MSAFP iss found to be 150.03 ± 50.65ng/ml. The reference range MAFP is found to be 51 to 294ng/ml. A significant negative correlationbetween MSAFP and respective BMI, as well as 1-minute Apgar  score of corresponding babies is observed. However no association is observed between the MSAFP and respective parity of the mother. This study reported the mean and preliminary reference range of MSAFP distribution in population of Sokoto State, Nigeria. This could be of help in the screening, diagnosis and monitoring of maternal/neonatal diseases during pregnancy.

Author Biography

A. A. Umar, Department of Morbid Anatomy and Forensic Medicine, Faculty of Basic Medical Sciences, College of Health Sciences Usmanu Danfodiyo University, Sokoto, Nigeria



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Published

2014-12-03

How to Cite

Abubakar, A. F., Das, S. C., Mainasara, A. S., Ben, O., Bello, A., & Umar, A. A. (2014). Pattern of Maternal Serum Alpha-Foetoprotein Immediately Post Partum in Sokoto State, Nigeria. International Journal of Health and Medical Information (IJHMI), 3(2&3), 23–27. Retrieved from http://icidr.org.ng/index.php/Ijhmi/article/view/663

Issue

Vol. 3 No. 2&3

Section

Articles

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