Effect of Aqueous Extract of Parkiabiglobosa Fruit Husk on Heamatological Parameters in Rats
Keywords:
Aqueous extract, Parkiabiglobosa fruit husk, heamatological parameters, ratsAbstract
The toxic effect of the aqueous extract of Parkiabiglobosa fruit husk on haematological parameters is studied in albino rats. The oral acute toxicity is conducted using the standard method of Karber as modified by Aliu and Nwude. The prolonged toxicity is evaluated by estimating the haematological parameters such as red blood cells (RBC), packed cell volume (PCV), haemoglobin concentration (Hb), white blood cells (WBC) count and the body weight. The results of the study show that the oral LD50 of the extract is 1120mg/kg b.w indicating that the extract is moderately toxic. The aqueous extract has no significant (p>0.05) effect on the RBC, HB and PCV but shows a significant (p<0.05) increase in WBC count on day 14-21. The body weight of the rats is significantly (p<0.05) increased by the administration of the extract which may imply that the extract is a taste receptor stimulant which stimulates appetite of the rats, thereby increasing feed consumption or the extract may have been responsible for depressing the satiety center leading to continuous consumption of feed resulting into increase body weight. In conclusion, the aqueous extract of Parkiabiglobosa fruit husk can be said to be safe but also with a significant (p<0.05) increase in total serum WBC count which may mean a possible stimulation of the immune system.
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