InvitroAnthelmintic Efficacy of Aqueous Extract of Parkiabiglobosa Fruit Husk on Albino Rats
Keywords:
Parkiabiglobosa fruit husk, albino rats, aqueous extract, herbs or plant productsAbstract
The toxicity and anthelmintic efficacy of the aqueous extract of Parkiabiglobosa fruit husk were studied in albino rats. The oral acute toxicity study was conducted using the standard method. The anthelmintic efficacy of the extract was conducted using the fecal and larval recovery test tube paper technique and the egg hatch assay. The result of the studies showed that the LD50 of the oral administration of the extract was 1120mg/kg b.w indicating that the extract was moderately toxic. The extract did not significantly reduce egg hatch as compared to levamisol and albendazole used in this study, hence does not have anthelmintic effect. In conclusion the aqueous extract of Parkiabiglobosa fruit husk can be said to be safe but does not possess anthelmintic activity.
References
Alabi D. A., Akinsulire O. R. and Sanyaolu M. A. (2005). Qualitative determination of Chemical and nutritional composition of Parkiabiglobosa (Jacq.). African Journal of Biotechnology, 4(8), 812-815.
Aliu, Y. O. and Nwude, N. (1982).Calculation of acute toxicity. Veterinary Pharmacology andToxicology experiments. Baraka press, ABU Zaria pp 104-107.
Aliu, Y. O. (2007). Veterinary Pharmacology. First ed. Zaria: Tamaza Publishing Company Limited. ANON (1997). Manual for Veterinary parasitology laboratory techniques. Technical Bulletin No.18, Ministry of Agriculture, Fisheries and Food. London pp. 129.
Ajaiyeoba, E. (2002). Phytochemistry and antibacterial properties of Parkiabiglobosa. African Journal of Biomedical Research, 5, 125-129. CIOMS (Council for International Organization of Medical Science). International Guiding Principles for Biomedical Research Involving Animals, 1985. Available at http://http//www.cioms.ch/ frame_1985_textof_guidelines.htm. Accessed on 26th July, 2011
Clarke, E. G. C. and Clarke, M. L. (1979). Toxicology rating: Veterinary Toxicology (2nd ed.) ELBS and Brallier, Tindal, New York, U.S.A.
Chiejina, S. N. (1984). Bovine parasitic gastroenteritis in Nsukka. Worm egg output and herbage infestation following dry season calving and performance of calves during their first grazing season. Tropical Veterinarian,2:128-132.
Dennis, V. P. (1994). Toxicology and Newborn. In: S. Kacerd and M. J. Reason (eds.). New York: Academic Publishers, U.S.A. pp 1-23.
Harada, Y. and Mori, O. (1995). A new method of culturing hook worm. YonagoActa Medicine, 1, 17.
Hammond J. A., Fielding D. and Bishop S. C. (1997). Prospect for anthelminics in tropical medicine. Veterinary Research Communications, 21, 213-228.
Hansen, J. and Perry, B. (1990). The epidemiology diagnosis and control of gastro-intestinal parasites of ruminant in Africa. ILRAD, Nairobi Kenya. Xt. P 121.
Ibrahim M. A., Nwude N. J., Aliu V. O. and Ogunsusi R. A. (1983).Traditional concept of animal disease and treatment among Fulani herdsmen in Kaduna state. Overseas development Institute Pastoral Development Network Paper.Irvine, F. R. (1961). Woody plants of Ghana. Oxford: University Press, London.
Karber, G. (1931). Contribution to the collective treatment of Pharmacology serial experiment. Arch. Exp. Path. Pharmacol., 165, 480-483.
Kelly, J. D., Webster, J. L. and Griffin, D. L. (1981). Resistance to benzimidazole anthelmintics in equine strongyle. Australian Vet. J. 57:163- 171.
Mead, R. and Curnow, R. N. (1983). Statistical methods in Agriculture and Experimental Biology. London: Chapman and Hall.
Monteiro A. M., Wanyangu S. W., Kariuki D. P., Bain R., Jackson F. and Mckeller Q. A. (1998). Pharmaceutical quality of anthelmintics sold in Kenya. Veterinary Record, 142:396-398.
Nwude, N. and Ibrahim, M. A. (1980). Plants used in Traditional Veterinary Medical Practice in Nigeria. Journal of Veterinary Pharmacology and Therapeutics, 12:46-50, 3:261-27..
Nwosu, M. O. (1998). Aspects of ethnobotanical medicine in Southeast Nigeria. Journal of trad. CAM, 4:305-310.
Orwa C., Mutua A., Kindt R., Jamnadass R. and Anthony S. (2009). Agroforestry Database: a tree reference and selective guide version, 4.0 (http://www.worldagroforestry.org/sites/treedbs/ treedatabases.asp)
Sabiti, E. N. and Cobbina, J. (1992). Parkiabiglobosa, a potential multipurpose fodder tree legume in West Africa. The International Tree Crops Journal, 7, 113-139
Soforowa, E. A. (1984). Ethnoveterinary remedies. Medicinal plants and Traditional in Afrca (1st Ed.). London: John Wiley and Sons Ltd. Pp 66-80, 180-188.
Soulsby, E. J. L. (1982). Helminthes, Arthropods and protozoa of domesticated animals (7th edition). London: U. K. Bailliere Tindal, p809.
Suleiman, M. M., Maman, Y. O., Aliu, J. O. and Ajanusi, 2005. Anthelmintic activity of crude methanol extract of Xylopiaaethropica against Nippostrongylusbrasilliensis in rats. Vet arhiv, 75, 487-495.
UNESCO (1996). Culture and Health, Orientation Texts- World Decade for Cultural Development 1988-1997. Documents CLT/DEC/PRO- 1996, France, p 129.
UNESCO (1998). FIT/504-RAF-48. Development of drugs and chemotherapeutics from plants. De Terminal Report Promotion of Ethnobotany and Sustainable Use of Plant Resources in Africa. p 60.
